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Organic compounds that contain an aromatic ring with one or more hydrogen atoms replaced by a halogen atom; also known as haloarene or halogenoarene. Halogen atoms include bromine, chlorine, fluorine, iodine.
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4-iodo-SAHA (CAS 1219807-87-0) is a hydrophobic analog of suberoylanilide hydroxamic acid (SAHA) that functions as a histone deacetylase (HDAC) inhibitor targeting both class I and II HDACs By blocking HDAC activity 4-iodo-SAHA modulates the reversible acetylation of lysine residues on histone and non-histone proteins affecting transcriptional regulation In cellular assays 4-iodo-SAHA demonstrated antiproliferative effects with EC50 values of 1 1 M in SKBR3 breast cancer cells and 0 95 0 12 0 24 0 85 and 1 3 M in HT29 U937 JA16 HL60 and K562 tumor cell lines respectively Notably it exhibited greater potency than SAHA in inhibiting proliferation of U937 leukemia cells These properties make 4-iodo-SAHA valuable for investigating HDAC-related cellular processes and cancer models
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More